Amplified Toxicity of Pollutants in Mixtures on Endocrine Disruption

Friday 4 July 2008


The pollutants tested are as follows: PCB, bisphenol A, nonylphenol (for insulators, plasticizers, additives of pesticides...), pesticides (atrazine, DDT, DDE, vinclozolin, chlordecone, tributylin, antifungal material painted onto boats) and a drug (diethylstilbestrol, marketed under the name of prohibited distilbene, in order to understand its action when it was administered during the fetal life of people who are sick today).

Many of these products still find their way into the human body, in particular via the food chain, or they are allowed by regulation. They act in combination to damage the organism, whereas they are much less active when they are alone. It was demonstrated that extended exposures to low doses generally amplify the endocrine disruptor effect by up to fifty times. The persistent accumulation of these products in organisms is of great concern when we examine both public health and the environment. Future evaluations under the pesticides and the REACH regulations will have to take much more careful account of the combinations of low doses which contaminate the environment.


Contact : Pr Gilles-Eric Séralini, CRIIGEN, Biochemistry, Institute of Biology, University of Caen, Esplanade de la Paix, 14032 Caen, France. 

E-mail: Phone: 33(0)2-31-56-56-84. Fax: 33(0)2-31-56-53-20. 

Corinne Lepage is President of CRIIGEN.


This study is supported by the Human Earth and Denis Guichard Foundations, CRIIGEN and the Conseil Régional de Basse-Normandie. This work follows others published this year on GM maize MON863 and on Roundup (see The title of this one is: Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disruptors alone and in combination by Nora BENACHOUR, Safa MOSLEMI, Herbert SIPAHUTAR and Gilles-Eric SERALINI. In: Toxicology and Applied Pharmacology.