Practical Food Safety: Contemporary Issues and Future Directions, First Edition. 632 pages
Edited by Rajeev Bhat and Vicente M. Gómez-López.
© 2014 John Wiley & Sons, Ltd. Published 2014 by John Wiley & Sons, Ltd.
Robin Mesnage and Gilles-Éric Séralini
University of Caen, CRIIGEN and Pole Risk MRSH-CNRS, Caen Cedex, France
Public policy is regularly shaken by health crises or unexpected discoveries; future directions in toxicology assessment are therefore urgently needed. This chapter focuses on agricultural genetically modified organisms (GMOs) because they are essentially pesticide-plants, designed to tolerate and/or produce new pesticide residues in food and feed. Moreover, the usual concepts of regulatory toxicology become erroneous or insufficient with regards to endocrine or nervous disruption, or epigenetic effects. Most pollutants affect cell-cell communication systems in the same way as unsolicited spam emails, and may promote chronic and environmental pathologies. We also describe how formulated pes ticides are mixtures which have not been investigated for their long-term toxicities. They contain adjuvants that are even more toxic than the sup posedly active principle. Finally, long-term and multigenerational testing in vivo often appears essential. This can be accomplished within two years on rats, independently of the biotechnology industry, with raw data being transparent to the scientific community to allow healthy debate before the next health crisis.